So I wrote a little thing for @MolMetab sciencedirect.com/science/articl As we now appreciate, GLP-1 can target multiple brain regions and neuronal populations to reduce food intake, and the clinical results are increasingly impressive #obesity The ongoing SELECT trial will be pivotal for the field sciencedirect.com/science/articl From very modest weight loss with exenatide twice daily, the GLP-1 field has learned, by titration, dose escalation, higher Cmax, and better molecules, to achieve clinically meaningful #weightloss #T2D #obesity More progress to come #obesity described here sciencedirect.com/science/articl Beyond semaglutide and tirzepatide, where might we find the next GLP-1-based advances in #weightloss #obesity Take a look at the slope of the lines for the combination of cagrilintide + semaglutide and make projections out to 52 weeks thelancet.com/journals/lance Join the conversation
In KLOW blends, KPV is included to broaden research focus beyond structural remodeling and into cytokine and inflammation marker models
However, researchers quickly realized that this localized elevation is not a sign of a healthy, robust immune system
Thus, oxidative stress, ER stress, apoptosis, and EMT were considered important in the pathogenesis of galactose-induced cataracts in this study (Fig
This is not a reason to dismiss the compound it is a reason to be honest about what we know and dont know
Tschopp J, Schroder K
